| Chemical Properties | Back Directory | [Boiling point ]
547.9±50.0 °C(Predicted) | [density ]
1.279±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
11.24±0.20(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC50 of ~1-3 μM[1]. | [in vivo]
7-BIA (10-20 mg/kg; given i.p.; only once) reduces cocaine self-administration in highly experienced WT mice[1]. | Animal Model: | WT mice (available cocaine 50 times, 1 mg/kg infusions on FR1 schedule during ≥20 prior sessions)[1] | | Dosage: | 10 mg/kg, 20 mg/kg | | Administration: | Given i.p.; only once | | Result: | Reduced cocaine self-administration in highly experienced WT mice. |
| [References]
[1] Uhl GR, et al. Cocaine reward is reduced by decreased expression of receptor-type protein tyrosinephosphatase D (PTPRD) and by a novel PTPRD antagonist. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11597-11602. DOI:10.1073/pnas.1720446115 |
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www.medchemexpress.com |
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