ChemicalBook--->CAS DataBase List--->1313881-70-7

1313881-70-7

1313881-70-7 Structure

1313881-70-7 Structure
IdentificationBack Directory
[Name]

AKT inhibitor 2
[CAS]

1313881-70-7
[Synonyms]

ARQ-092
CS-2349
Miransertib
ARQ092;ARQ 092
AKT inhibitor 2
ARQ 092 Free Base
3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenylimidazo[4,5-b]pyridin-2-yl]pyridin-2-amine
2-Pyridinamine, 3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl]-
[Molecular Formula]

C27H24N6
[MDL Number]

MFCD30187510
[MOL File]

1313881-70-7.mol
[Molecular Weight]

432.52
Chemical PropertiesBack Directory
[Boiling point ]

700.8±70.0 °C(Predicted)
[density ]

1.35±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO:8.0(Max Conc. mg/mL);18.5(Max Conc. mM)
[form ]

A crystalline solid
[pka]

9.17±0.20(Predicted)
[color ]

Off-white to yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS08
[Signal word ]

Warning
[Hazard statements ]

H373
[Precautionary statements ]

P260-P314-P501
Hazard InformationBack Directory
[Uses]

3-[3-[4-(1-Aminocyclobutyl)phenyl]-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl]-2-pyridinamine is a selective allosteric inhibitor of AKT kinases.
[in vivo]

Miransertib (ARQ-092; Compound 21a) shows good absolute oral bioavailability in rats (5 mg/kg) and monkeys (10 mg/kg) with F values of 62% and 49%, respectively. The half-life is longer in rats compared to monkeys with t1/2 values of 17 h in rats versus 7 h in monkeys. The Cmax is 198 ng/mL and 258 ng/mL and the AUCinf was 5496 h ng/mL and 2960 h ng/mL in rats and monkeys, respectively[1].
Miransertib (ARQ-092; Compound 21a) inhibits tumor growth in a human xenograft mouse model of endometrial adenocarcinoma[1].

[IC 50]

Akt1: 2.7 nM (IC50); Leishmania; Akt3: 8.1 nM (IC50); Akt2: 14 nM (IC50); Akt1 E17K mutant
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