| Identification | Back Directory | [Name]
N-Methylleukotriene C4 | [CAS]
131391-65-6 | [Synonyms]
NMLTC4
N-METHYL LTC4
N-Methylleukotriene C4
FPLBRCJNODNRQZ-UYCXAPQFSA-N
N methyl Leukotriene C4,N-methyl Leukotriene C-4,Nmethyl Leukotriene C4
Glycine, N-methyl-L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]-L-cysteinyl-
N-[S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-Carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetren-1-yl]-N-(L-γ-glutamyl)-L-cysteinyl]-N-methylglycine | [Molecular Formula]
C31H49N3O9S | [MDL Number]
MFCD11113154 | [MOL File]
131391-65-6.mol | [Molecular Weight]
639.81 |
| Chemical Properties | Back Directory | [Boiling point ]
965.7±65.0 °C(Predicted) | [density ]
1.202±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 1 mg/ml; Ethanol:H20 (95:5): 2 mg/ml; PBS (pH 7.2): 100 μg/ml | [pka]
2.23±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
N-methyl Leukotriene C4 is synthetic analog of LTC4 with decreased binding affinity. | [Uses]
Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult. N-methyl Leukotriene C4 (N-methyl LTC4) is a synthetic analog of LTC4 that is not readily metabolized to LTD4 and LTE4.It acts as a potent and selective CysLT2 receptor agonist exhibiting EC50 values of 122 and > 2,000 nM at the human CysLT2 and CysLT1 receptors, respectively. It has essentially the same potency as LTC4 at both the human and murine receptors CysLT2 receptors. N-methyl LTC4 is potent and active in vivo, causing vascular leak in mice overexpressing the human CysLT2 receptor but not in CysLT2 receptor knockout mice. | [storage]
Store at -20°C |
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