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1314021-57-2

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1314021-57-2 Structure

1314021-57-2 Structure
IdentificationBack Directory
[Name]

ARQ 069
[CAS]

1314021-57-2
[Synonyms]

ARQ 069
Benzo[h]quinazolin-2-amine, 5,6-dihydro-6-phenyl-, (6S)-
[Molecular Formula]

C18H15N3
[MDL Number]

MFCD34469136
[MOL File]

1314021-57-2.mol
[Molecular Weight]

273.33
Chemical PropertiesBack Directory
[Boiling point ]

494.4±53.0 °C(Predicted)
[density ]

1.248±0.06 g/cm3(Predicted)
[pka]

3.81±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

ARQ 069, an analog of ARQ 523, inhibits FGFR in an enantiospecific manner. ARQ 069 targets the unphosphorylated, inactive forms of FGFR1/FGFR2 kinases (IC50s of 0.84 μM and 1.23 μM, respectively). ARQ 069 inhibits FGFR1/FGFR2 autophosphorylation (IC50s of 2.8 and 1.9 μM, respectively) through a mechanism in a non-ATP competitive dependent manner[1].
[IC 50]

unphosphorylated FGFR1: 0.84 μM (IC50); unphosphorylated FGFR2: 1.23 μM (IC50); FGFR1 autophosphorylation: 2.8 μM (IC50); FGFR2 autophosphorylation: 1.9 μM (IC50)
[References]

[1] Eathiraj S, et al. A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor. J Biol Chem. 2011 Jun 10;286(23):20677-87. DOI:10.1074/jbc.M110.213736
1314021-57-2 suppliers list
Company Name: TargetMol Chemicals Inc.
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Website: https://www.targetmol.com/
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Website: https://www.targetmol.com/
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
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Company Name: TargetMol Chemicals Inc.  
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