| Identification | Back Directory | [Name]
BRD50837 | [CAS]
1314295-24-3 | [Synonyms]
BRD50837
Cyclopropanecarboxamide, N-[(2R,3S)-2-[[[(4-chlorophenyl)sulfonyl]methylamino]methyl]-3,4,5,6-tetrahydro-5-[(1R)-2-hydroxy-1-methylethyl]-3-methyl-6-oxo-2H-1,5-benzoxazocin-10-yl]- | [Molecular Formula]
C26H32ClN3O6S | [MOL File]
1314295-24-3.mol | [Molecular Weight]
550.07 |
| Hazard Information | Back Directory | [Description]
BRD50837 is a potent and selective Sonic Hedgehog (Shh) inhibitor. The Hedgehog signaling pathway is involved in the development of multicellular organisms and, when deregulated, can contribute to certain cancers, among other diseases. | [Uses]
BRD50837 is a potent inhibitor of Sonic Hedgehog (Shh), with the EC50 of 0.09 μM. BRD50837 plays an important role in cancer research[1]. | [References]
[1] Taikangxiang Yun, et al. Discovery of Small-Molecule Modulators of the Sonic Hedgehog Pathway. Front Chem. 2020 Jun 16:8:498. DOI:10.3389/fchem.2020.00498 |
|
|