| Identification | Back Directory | [Name]
A 70874 | [CAS]
131449-37-1 | [Synonyms]
A 70874
Nα-(tert-Butyloxycarbonyl)-L-Trp-N-[2-(4-hydroxyphenyl)ethenylcarbonyl]-L-Phe-methyl NH2 | [Molecular Formula]
C45H55N7O10 | [MOL File]
131449-37-1.mol | [Molecular Weight]
853.97 |
| Hazard Information | Back Directory | [Description]
A 70874 has high potency and selectivity for cholecystokinin (CCK) A receptors. | [Uses]
A-70874 is a tyrosine-free tetrapeptide analog of cholecystokinin (30-33) (CCK-4). A-70874 is an agonist that stimulates pancreatic amylase release and a partial agonist that stimulates pancreatic phosphoinositide decomposition. A-70874 has an IC50 of 4.9 nM for the guinea pig pancreatic CCK receptor. Cholecystokinin (CCK) receptors are divided into CCK-A (digestive tract) and CCK-B (brain). A-70874 has an affinity of 1.6 μM for the CCK-B/gastrin receptor[1]. | [References]
[1] Lin CW, et al. Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. Mol Pharmacol. 1991 Mar;39(3):346-51. PMID:1706470 |
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