| Identification | Back Directory | [Name]
NG-25 | [CAS]
1315355-93-1 | [Synonyms]
NG25
NG-25
NG 25; NG-25
HG-7-92-01
(NG 25)
NG-25 ISO 9001：2015 REACH
N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide
N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide
3-((1H-Pyrrolo[2,3-b]pyridin-4-yl)oxy)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide
3-((1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3v-(trifluoromethyl)phenyl)-4-methylbenzamide
Benzamide, N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)- | [Molecular Formula]
C29H30F3N5O2 | [MDL Number]
MFCD19443255 | [MOL File]
1315355-93-1.mol | [Molecular Weight]
537.58 |
| Chemical Properties | Back Directory | [density ]
1.313±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMSO | [form ]
powder | [pka]
12.91±0.70(Predicted) | [color ]
white to beige | [Water Solubility ]
H2O: 5mg/mL, clear | [InChIKey]
SMPGEBOIKULBCT-UHFFFAOYSA-N | [SMILES]
C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)(=O)C1=CC=C(C)C(OC2C=CN=C3NC=CC3=2)=C1 |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS06 | [Signal word ]
Danger | [Hazard statements ]
H301-H413 | [Precautionary statements ]
P273-P301+P310+P330 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
WGK 3 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Aquatic Chronic 4 |
| Hazard Information | Back Directory | [Uses]
NG 25 inhibits TGF-beta-activated kinase 1 (TAK1). It also inhibits LYN, mitogen-activated protein kinase (MAP4K2) and Abl kinase activity. | [Biochem/physiol Actions]
NG25 is potent multiple kinase inhibitor belonging to type II kinase inhibitors class that binds to kinase ATP binding pocket at not ready to catalyze conformation. NG25 is used as a potent dual inhibitor of TAK1 (TGFβ-Activated Kinase 1, MAP3K7) and MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2; GCK) kinases. NG25 inhibits the activation of IKKa/IKKb and prevents the secretion of type 1 IFNs by TLR2 and TLR9 agonist. | [IC 50]
MAP4K2: 21.7 nM (IC50); TAK1: 149 nM (IC50); LYN: 12.9 nM (IC50); GSK: 56.4 nM (IC50); ABL,ARG: 75.2 nM (IC50); FER: 82.3 nM (IC50); SRC: 113 nM (IC50); Eph B2: 672 nM (IC50); ZAK: 698 nM (IC50); Eph A2: 773 nM (IC50); Eph B4: 999 nM (IC50); ZC1/HGK: 3250 nM (IC50); RAF1: 7590 nM (IC50) | [storage]
Store at -20°C |
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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