| Identification | Back Directory | [Name]
Phosphonic acid, P,P'-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-, sodium salt (1:2) | [CAS]
131654-46-1 | [Synonyms]
Phosphonic acid, P,P'-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-, sodium salt (1:2) | [Molecular Formula]
C5H11N2NaO7P2 | [MDL Number]
MFCD09839324 | [MOL File]
131654-46-1.mol | [Molecular Weight]
296.09 |
| Hazard Information | Back Directory | [Uses]
Zoledronate (CGP 42446) disodium is a potent bisphosphonate that effectively inhibits osteoclastogenesis, reducing bone turnover and stabilizing the bone matrix. Zoledronate disodium has demonstrated notable effectiveness in managing Paget's disease of bone by suppressing metabolic activity and alleviating bone pain. Zoledronate disodium is being investigated in the ongoing ZiPP trial for its potential to prevent disease progression in patients with Paget's disease. Zoledronate disodium also exhibits diverse anti-tumor effects in osteosarcoma, further highlighting its multifunctional therapeutic applications. | [References]
[1] Bisphosphonates in the management of Paget's disease DOI:10.1016/j.bone.2020.115465 |
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