| Identification | Back Directory | [Name]
Fulvestrant (ICI 182780) S enantiomer | [CAS]
1316849-17-8 | [Synonyms]
ZD 9238 S enantiomer
ZM 182780 S enantiomer
ICI 182780 S enantiomer
Fulvestrant S enantiomer
Fulvestrant (ICI 182780) S enantiomer
Fulvestrant impurity 11/Fulvestrant S enantiomer
Estra-1,3,5(10)-triene-3,17-diol, 7-[9-[(S)-(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]-, (7α,17β)- | [Molecular Formula]
C32H47F5O3S | [MDL Number]
MFCD31619291 | [MOL File]
1316849-17-8.mol | [Molecular Weight]
606.77 |
| Chemical Properties | Back Directory | [Boiling point ]
674.8±55.0 °C(Predicted) | [density ]
1.201±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
10.27±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Fulvestrant S enantiomer (ICI 182780 S enantiomer) is the S enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC50 of 9.4 nM. | [storage]
Store at -20°C | [References]
[1] Caprioglio D, et al. An alternative synthesis of the breast cancer drug fulvestrant (Faslodex?): catalyst control over C-C bond formation. Chem Commun (Camb). 2015;51(80):14866-14868. DOI:10.1039/c5cc05805h
[2] Wakeling AE, et al. A potent specific pure antiestrogen with clinical potential. Cancer Res. 1991;51(15):3867-3873. PMID:1855205 |
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