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131774-53-3

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131774-53-3 Structure

131774-53-3 Structure
IdentificationBack Directory
[Name]

KS 505a
[CAS]

131774-53-3
[Synonyms]

KS 505a
Longestin
β-D-Glucopyranosiduronic acid, (1R,2S,4R,4aR,4bS,6R,6aS,6bS,8aR,8bS,10aS,17aS,17bR,19aS,19bR,21aS,21bS,23aR)-1-carboxy-2,3,4,4a,4b,5,6,6a,6b,7,8,8a,8b,9,10,10a,14,16,17,17a,17b,18,19,19a,19b,20,21,21a,21b,22,23,23a-dotriacontahydro-14-hydroxy-8a,10a-bis(hydroxymethyl)-14-(3-methoxy-3-oxopropyl)-1,4,...
[Molecular Formula]

C61H88O17
[MDL Number]

MFCD32263214
[MOL File]

131774-53-3.mol
[Molecular Weight]

1093.35
Hazard InformationBack Directory
[Description]

Longestin is a trypanocidal agent; isolated from Steptomyces argenteolus; inhibits brain calcium- and calmodulin-dependent cyclic nucleotide phosphodiesterase.
[Uses]

Longestin (KS-505a) is a specific inhibitor of phosphodiesterase with antitrypanosomal activity, which is derived from Streptomyces argenteolus. Longestin is promising for research of anti-amnesia agent[1][2].
[References]

[1] Ozaki T, et al. Enzymatic Formation of a Skipped Methyl-Substituted Octaprenyl Side Chain of Longestin (KS-505a): Involvement of Homo-IPP as a Common Extender Unit. Angew Chem Int Ed Engl. 2018 May 28;57(22):6629-6632. DOI:10.1002/anie.201802116
[2] Hayashi Y, et al. Cloning of the gene cluster responsible for biosynthesis of KS-505a (longestin), a unique tetraterpenoid. Biosci Biotechnol Biochem. 2007 Dec;71(12):3072-81. DOI:10.1271/bbb.70477
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