| Identification | Back Directory | [Name]
Benzamide, 3-[[(16β,17β)-3-(2-bromoethyl)-17-hydroxyestra-1,3,5(10)-trien-16-yl]methyl]- | [CAS]
1318265-18-7 | [Synonyms]
PBRM
Benzamide, 3-[[(16β,17β)-3-(2-bromoethyl)-17-hydroxyestra-1,3,5(10)-trien-16-yl]methyl]- | [Molecular Formula]
C28H34BrNO2 | [MOL File]
1318265-18-7.mol | [Molecular Weight]
496.48 |
| Hazard Information | Back Directory | [Uses]
17β-HSD1-IN-2 (PBRM) is a non-estrogenic and steroidal covalent irreversible inhibitor of 17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) (Ki=368 nM). 17β-HSD1-IN-2 can be used for the research of estrogen-dependent disorders[1]. | [References]
[1] Trottier A, et al. Insight into the mode of action and selectivity of PBRM, a covalent steroidal inhibitor of 17β-hydroxysteroid dehydrogenase type 1. Biochem Pharmacol. 2017 Nov 15;144:149-161. DOI:10.1016/j.bcp.2017.08.004 |
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