| Identification | Back Directory | [Name]
RO-31-8425 | [CAS]
131848-97-0 | [Synonyms]
RO-31-8425
Ro 31-8245
RSYYBisindolylmaleimideXhydrochloride
Ro-31-8425 - CAS 131848-97-0 - Calbiochem
BisindolylMaleiMide X . hydrochloride [Ro 31-8425]
3-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione | [Molecular Formula]
C26H24N4O2 | [MDL Number]
MFCD04972010 | [MOL File]
131848-97-0.mol | [Molecular Weight]
424.49 |
| Chemical Properties | Back Directory | [Boiling point ]
736.1±60.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
0-6°C | [solubility ]
DMSO: 10mg/mL | [form ]
Red to orange-red solid | [pka]
7.91±0.60(Predicted) | [color ]
red to orange-red |
| Hazard Information | Back Directory | [Uses]
Bisindolylmaleimide X is a selective inhibitor of PKC, also inhibits Cdk2 and GSK-3β. | [Biological Activity]
Cell permeable: yes''Primary Target
PKC''Product competes with ATP.''Reversible: yes''Target IC50: 15 nM for r at brain PKC; 8 nM for PKCα8 nM for PKCβI14 nM for PKCβII13 nM for PKCγand 39 nM for PKCε |
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| Company Name: |
TOSUN PHARM
|
| Telephone: |
020-66392521-118 18922260391 |
| Website: |
www.toref.cn/ |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|