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131999-28-5

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131999-28-5 Structure

131999-28-5 Structure
IdentificationBack Directory
[Name]

1H-Isoindole-1,3(2H)-dione, 2-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-
[CAS]

131999-28-5
[Synonyms]

5-HT6/7 antagonist 1
1H-Isoindole-1,3(2H)-dione, 2-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-
[Molecular Formula]

C22H20FN3O3
[MDL Number]

MFCD30747897
[MOL File]

131999-28-5.mol
[Molecular Weight]

393.41
Chemical PropertiesBack Directory
[Boiling point ]

565.6±50.0 °C(Predicted)
[density ]

1.346±0.06 g/cm3(Predicted)
[pka]

7.86±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

5-HT6/7 antagonist 1 is a multifunctional ligand that antagonizes 5-HT6/7/2A and D2 receptors, without interacting with M1 receptors and hERG channels.
[IC 50]

5-HT6 Receptor; 5-HT7 Receptor; 5-HT2A Receptor; D2 Receptor
[References]

[1] Ko?aczkowski M, et al. Novel arylsulfonamide derivatives with 5-HT?/5-HT? receptor antagonism targeting behavioral and psychological symptoms of dementia. J Med Chem. 2014 Jun 12;57(11):4543-57. DOI:10.1021/jm401895u
Spectrum DetailBack Directory
[Spectrum Detail]

1H-Isoindole-1,3(2H)-dione, 2-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-(131999-28-5)1HNMR
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