| Identification | Back Directory | [Name]
SBI-0640726 | [CAS]
1321827-45-5 | [Synonyms]
SBI-0640726
2(1H)-Quinolinone, 6-chloro-3-[(2E)-1-oxo-3-(2-pyridinyl)-2-propen-1-yl]-4-phenyl- | [Molecular Formula]
C23H15ClN2O2 | [MOL File]
1321827-45-5.mol | [Molecular Weight]
386.83 |
| Chemical Properties | Back Directory | [Boiling point ]
628.074±55.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.345±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
9.021±0.70(predicted) |
| Hazard Information | Back Directory | [Uses]
SBI-0640726 is an eIF4G1 inhibitor with antiproliferative activity in melanoma. SBI-0640726 disrupts the eIF4F translation initiation complex by inhibiting AKT and NF-kB signaling pathways. SBI-0640726 inhibits the growth of NRAS and BRAF mutant melanoma in vitro[1]. | [References]
[1] Yongmei Feng, et al. "SBI-0640756 attenuates the growth of clinically unresponsive melanomas by disrupting the eIF4F translation initiation complex." Cancer research 75.24 (2015): 5211-5218. DOI:10.1158/0008-5472.CAN-15-0885 |
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