| Identification | Back Directory | [Name]
1H-Purine-1-acetamide, 2,3,6,7-tetrahydro-3,7-dimethyl-N-(4-methylphenyl)-2,6-dioxo- | [CAS]
1323883-62-0 | [Synonyms]
1H-Purine-1-acetamide, 2,3,6,7-tetrahydro-3,7-dimethyl-N-(4-methylphenyl)-2,6-dioxo- | [Molecular Formula]
C16H17N5O3 | [MOL File]
1323883-62-0.mol | [Molecular Weight]
327.34 |
| Hazard Information | Back Directory | [Uses]
T-1-PMPA is a potent EGFR inhibitor with apoptotic properties. T-1-PMPA effectively inhibits EGFRWT and EGFR790m, with IC50 values of 86 nM and 561.73 nM, respectively[1]. | [IC 50]
EGFRWT: 86 nM (IC50); EGFRT790M: 561.73 nM (IC50) | [References]
[1] Ibrahim H Eissa, et al. New Theobromine Apoptotic Analogue with Anticancer Potential Targeting the EGFR Protein: Computational and In Vitro Studies. ACS Omega. 2024 Mar 27;9(14):15861-15881. DOI:10.1021/acsomega.3c08148 |
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