| Identification | Back Directory | [Name]
TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE | [CAS]
132414-81-4 | [Synonyms]
5-N-Boc-hexahydro-pyrrolo[3,4-b]pyrrole
Tert-butyl 2,7-diazabicyclo[3.3.0]octan-7-carboxylate
tert-butyl octahydropyrrolo[3,4-b]pyrrole-5-carboxylate
t-butyl hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate
5-Methyl-2-(1-Methylethoxy)-4- (4-piperidinyl)- BenzenaM
TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLAT
TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE
Hexahydropyrrolo[3,4-b]pyrrole-5-carboxylic acid tert-butyl ester
Octahydro-pyrrolo[3,4-b]pyridine-6-carboxylic acid tert-butyl ester
tert-Butyl 2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[2,3-c]pyrrole-5-carboxylate
(3aR*,6aR*)-hexahydro-pyrrolo[3,4-b]pyrrole-5-carboxylic acid tert-butyl ester
Pyrrolo[3,4-b]pyrrole-5(1H)-carboxylic acid, hexahydro-, 1,1-diMethylethyl ester | [Molecular Formula]
C11H20N2O2 | [MDL Number]
MFCD08235016 | [MOL File]
132414-81-4.mol | [Molecular Weight]
212.29 |
| Chemical Properties | Back Directory | [Boiling point ]
295.4±13.0 °C(Predicted) | [density ]
1.076±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
solid | [pka]
10.72±0.20(Predicted) | [Appearance]
Colorless to light yellow Liquid |
| Hazard Information | Back Directory | [Synthesis]
GENERAL STEPS: 1-benzyl-5-BOC-hexahydropyrrolo[3,4-B]pyrrole (1.68 g, 5.5 mmol) was dissolved in methanol (40 mL) under a nitrogen atmosphere, ammonium formate (3.5 g, 55.5 mmol) and palladium/carbon catalyst (600 mg) were added. The reaction mixture was heated to reflux for 2 h, subsequently cooled to room temperature and filtered through filter paper padded with methanol. The filtrate was concentrated under reduced pressure and the resulting residue was dissolved in dichloromethane and washed with sodium bicarbonate solution. The organic phase was separated, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 5-Boc-hexahydropyrrolo[3,4-B]pyrrole (1.1 g, 93% yield) as a gray oil. Mass spectrum (m/z): 213.2 [M+H]+. | [References]
[1] Patent: WO2017/21920, 2017, A1. Location in patent: Paragraph 0637; 0638 |
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