| Identification | Back Directory | [Name]
CDC | [CAS]
132465-11-3 | [Synonyms]
CDC
CDC 5-LO inhibitor
CDC lipoxygenase inhibitor
-3,4-dihydroxy-α-cyanocinnamate
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate
CINNAMYL-3,4-DIHYDROXY-ALPHA-CYANOCINNAMATE
Cinnamyl 3,4-dihydroxy-alpha-cyanocinnamate
CDC
1-Cyclohexy1-3-(3-dimethylamino proply)carbodilimide methiodide
(E,Z)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acid 3-phenyl-2-propenyl ester
2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, 3-phenyl-2-propen-1-yl ester, (2E)- | [Molecular Formula]
C19H15NO4 | [MDL Number]
MFCD00210839 | [MOL File]
132465-11-3.mol | [Molecular Weight]
321.33 |
| Chemical Properties | Back Directory | [Boiling point ]
583.9±50.0 °C(Predicted) | [density ]
1.326±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: ≥15mg/mL | [form ]
powder | [pka]
8.75±0.10(Predicted) | [color ]
light yellow to yellow | [InChI]
1S/C19H15NO4/c20-13-16(11-15-8-9-17(21)18(22)12-15)19(23)24-10-4-7-14-5-2-1-3-6-14/h1-9,11-12,21-22H,10H2/b7-4+,16-11+ | [InChIKey]
XGHYFEJMJXGPGN-UYHGDYIZSA-N | [SMILES]
Oc1ccc(cc1O)\C=C(/C#N)C(=O)OC\C=C\c2ccccc2 |
| Hazard Information | Back Directory | [Uses]
CDC is an inhibitor of 5-LO, 12-LO, and 15-LO. | [Biological Activity]
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is a potent and direct inhibitor of 5-LO (5-Lipoxygenase) th at reduces 5-LO activity in cell-free assays. CDC also inhibits 12-LO and 15-LO | [in vivo]
The high glucose and 12(S)-hydroxyeicosatetraenoic acid (HETE) could alter vascular endothelial (VE)-cadherin and β‐catenin phosphorylation levels, but did not alter total protein expression. However, the 12/15-LO inhibitor, Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC), antagonized the effect of high glucose on protein phosphorylation to mitigate destruction of the endothelial cell barrier, and the mouse diabetes mellitus model further confirmed these conclusions[1]. |
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