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132523-92-3

132523-92-3 Structure

132523-92-3 Structure
IdentificationBack Directory
[Name]

CK 3197
[CAS]

132523-92-3
[Synonyms]

CK 3197
1-Benzoyl-4-ethyl-5-[4-(2-methyl-2-imidazolin-1-yl)benzoyl]-1H-imidazol-2(3H)-one
[Molecular Formula]

C23H22N4O3
[MOL File]

132523-92-3.mol
[Molecular Weight]

402.45
Chemical PropertiesBack Directory
[density ]

1.29±0.1 g/cm3(Predicted)
[pka]

9.21±0.70(Predicted)
Hazard InformationBack Directory
[Description]

CK 3197 is a selective positive inotropic agent for the treatment of congestive heart failure. It has hemodynamic and myocardial energetic effects.
[Uses]

CK-3197 is a weak inhibitor of Peak lll cyclic 3'5'-adenosine monophosphate phosphodiesterase (CAMP PDEl). CK-3197 has hemodynamic and myocardial energetic effects in vivo. CK-3197 is an imidazolone derivative used as a selective positive inotropic agent for congestive heart failure[1].
[References]

[1] Greenberg S, et al. Hemodynamic and myocardial energetic effects of CK-3197, a selective positive inotropic agent. J Cardiovasc Pharmacol. 1991 Jan;17(1):145-53. DOI:10.1097/00005344-199101000-00021
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