| Identification | Back Directory | [Name]
9H-Pyrido[3,4-b]indol-3-amine, N-[(3-phenoxyphenyl)methyl]- | [CAS]
1327080-54-5 | [Synonyms]
3-(3-Phenoxybenzyl)amino-β-carboline
9H-Pyrido[3,4-b]indol-3-amine, N-[(3-phenoxyphenyl)methyl]- | [Molecular Formula]
C24H19N3O | [MOL File]
1327080-54-5.mol | [Molecular Weight]
365.43 |
| Hazard Information | Back Directory | [Uses]
3-(3-Phenoxybenzyl)amino-β-carboline is a potent tubulin inhibitor. 3-(3-Phenoxybenzyl)amino-β-carboline promotes selective degradation of αβ-tubulin heterodimers. 3-(3-Phenoxybenzyl)amino-β-carboline induces G2/M phase cell cycle arrest and apoptosis. 3-(3-Phenoxybenzyl)amino-β-carboline exhibits anticancer activity[1]. | [References]
[1] Yang J, et al. Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond. J Med Chem. 2022 Jun 28. DOI:10.1021/acs.jmedchem.2c00379 |
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