| Identification | Back Directory | [Name]
3-methyl-1H-pyrazol-5-ol | [CAS]
132712-71-1 | [Synonyms]
3-methyl-1H-pyrazol-5-ol
5-Methyl-2H-pyrazol-3-ol
1H-Pyrazol-5-ol, 3-Methyl- | [Molecular Formula]
C4H6N2O | [MDL Number]
MFCD00462188 | [MOL File]
132712-71-1.mol | [Molecular Weight]
98.1 |
| Chemical Properties | Back Directory | [Boiling point ]
309.7±22.0 °C(Predicted) | [density ]
1.296±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [pka]
3.51±0.23(Predicted) | [Appearance]
Off-white to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of compound (CAS:5953-85-5), compound (CAS:17356-08-0), urea and 3-methyl-1H-pyrazol-5-ol from compound (CAS:161374-07-8) was as follows: a-h of DHH (0.01 mol) was mixed with excess hydrazine hydrate (5 mL) and heated to reflux for 6 hr. . After completion of the reaction, the mixture was cooled and poured into crushed ice. The solid products a-d were collected by filtration, crystallized with ethanol and finally dried. Evaporation of the filtrate gave a solid residue, which was isolated by graded crystallization from water to obtain pyrazole and urea (a) or thiourea (b).
2.4.1. Synthesis of 3-methyl-1H-pyrazol-5-ol (13). Yield: 42-55% (based on a-h); Melting point: 221-223 °C (literature value [49]: 220-222 °C); 1H-NMR (DMSO-d6) δ (ppm): 2.47 (s, 3H, -CH3), 6.83 (s, 1H, Ar-H), 10.07 (s, 1H, OH), 12.10 (s, 1H, NH) . | [References]
[1] Journal of Chemistry, 2018, vol. 2018, |
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