| Identification | Back Directory | [Name]
1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine | [CAS]
132834-56-1 | [Synonyms]
1-(6-Chloro-5-(trifluoromethyl)
1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine
Piperazine, 1-[6-chloro-5-(trifluoromethyl)-2-pyridinyl]- | [Molecular Formula]
C10H11ClF3N3 | [MDL Number]
MFCD00892750 | [MOL File]
132834-56-1.mol | [Molecular Weight]
265.66 |
| Chemical Properties | Back Directory | [Melting point ]
76～78℃ | [Boiling point ]
387.1±42.0 °C(Predicted) | [density ]
1.352±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMSO: 250 mg/mL (941.05 mM) | [form ]
Solid | [pka]
8.38±0.10(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively[1][3].Org-12962 displays antiaversive effects in a rat model of panic-like anxiety[2]. | [in vivo]
Org-12962 (intraperitoneal injection; 0.3-3.2 mg/kg) significantly increases the postinjection frequency thresholds for self-interruption (F3.71=11.40). Org-12962 is dissolved or microsuspended in 0.3% v/v Tween 80 in physiological saline (NaCl 0.9%)[1]. | Animal Model: | Male Wistar rats[2] | | Dosage: | 0.3 mg/kg, 1 mg/kg, 3.2 mg/kg | | Administration: | Intraperitoneal injection; 0.3-3.2 mg/kg | | Result: | Induced a dose-related antipanic-like effect in rat. |
| [IC 50]
5-HT2C Receptor: 7.01 (pEC50); 5-HT2A Receptor: 6.38 (pEC50); 5-HT2B Receptor: 6.28 (pEC50) | [References]
[1] Porter RH,et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.Br J Pharmacol. 1999 Sep;128(1):13-20. DOI:10.1038/sj.bjp.0702751
[2] Jenck F, et al. Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.Eur Neuropsychopharmacol. 1998 Aug;8(3):161-8. DOI:10.1016/s0924-977x(97)00055-2
[3] Faassen F, et al. Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.Int J Pharm. 2003 Sep 16;263(1-2):113-22. DOI:10.1016/s0378-5173(03)00372-7 |
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