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1328934-40-2

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1328934-40-2 Structure

1328934-40-2 Structure
IdentificationBack Directory
[Name]

7-cyclopentyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]-N,N-bis(trideuteriomethyl)pyrrolo[2,3-d]pyrimidine-6-carboxamide
[CAS]

1328934-40-2
[Synonyms]

[2H6]-LEE011
7-cyclopentyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]-N,N-bis(trideuteriomethyl)pyrrolo[2,3-d]pyrimidine-6-carboxamide
[Molecular Formula]

C23H24D6N8O
[MOL File]

1328934-40-2.mol
[Molecular Weight]

440.574
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

LEE011-d6 is the isotope analog of LEE011(L321000). LEE011 is an orally bioavailable and highly specific CDK4/6 (cyclin-dependent kinase 4/6) inhibitor. LEE011 in combination with LGX818 (a V600E BRAF specific inhibitor) or BYL719 (a PIK3CA specific inhibitor) leads to robust anti-tumor activity in melanoma and breast cancer tumor models.
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