| Identification | Back Directory | [Name]
Ethanamine, 2-[[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]oxy]- | [CAS]
133162-24-0 | [Synonyms]
β-Aminoarteether
Ethanamine, 2-[[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]oxy]- | [Molecular Formula]
C17H29NO5 | [MDL Number]
MFCD34470920 | [MOL File]
133162-24-0.mol | [Molecular Weight]
327.42 |
| Chemical Properties | Back Directory | [Boiling point ]
421.0±45.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [form ]
Oil | [pka]
8.46±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
β-Aminoarteether (SM934 free base) is an Artemisinin derivative with orally active. β-Aminoarteether can be used for inflammation and autoimmune disease research, such as lupus diseases[1]. | [Definition]
ChEBI: Beta-aminoarteether is an artemisinin derivative in which the lactone of (+)-artemisinin has been converted into the corresponding lactol 2-aminoethyl ether [beta (S) configuration at the new stereocentre]. It is an artemisinin derivative and a primary amino compound. | [in vivo]
β-Aminoarteether (SM934; 1-10 mg/kg; oral administration; daliy; for 3 months) treatment significantly delays the progression of glomerulonephritis and increases the survival rate of NZB/W F1 mice. β-Aminoarteether treatment promots the IL-10 production of macrophages from NZB/W F1 mice[1]. | Animal Model: | Female NZB/W F1 mice (Six and half months old)[1] | | Dosage: | 1 mg/kg, 3 mg/kg, and 10 mg/kg | | Administration: | Oral administration; daliy; for 3 months | | Result: | Significantly delayed the progression of glomerulonephritis and increased the survival rate of NZB/W F1 mice. |
| [References]
[1] Li-Fei Hou, et al. SM934 treated lupus-prone NZB × NZW F1 mice by enhancing macrophage interleukin-10 production and suppressing pathogenic T cell development. PLoS One. 2012;7(2):e32424. DOI:10.1371/journal.pone.0032424
[2] Yang FM, Fan D, Yang XQ, et al. The artemisinin analog SM934 alleviates dry eye disease in rodent models by regulating TLR4/NF-κB/NLRP3 signaling. Acta Pharmacol Sin. 2021;42(4):593-603. DOI:10.1038/s41401-020-0484-5 |
| Spectrum Detail | Back Directory | [Spectrum Detail]
Ethanamine, 2-[[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]oxy]-(133162-24-0)1HNMR
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MedChemExpress
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021-58955995 |
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www.medchemexpress.com |
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