| Identification | Back Directory | [Name]
Nav1.7-IN-2 | [CAS]
1332295-35-8 | [Synonyms]
Nav1.7-IN-2
Nav1.7 inhibitor 2
Nav-1.7-IN-2,Nav1.7 IN 2,Nav1.7IN2
3-[[4-[3-(4-fluoro-2-methylphenoxy)-1-azetidinyl]-2-pyrimidinyl]amino]-N-methyl-
Benzamide,3-[[4-[3-(4-fluoro-2-methylphenoxy)-1-azetidinyl]-2-pyrimidinyl]amino]-N-methyl- | [Molecular Formula]
C22H22FN5O2 | [MDL Number]
MFCD29472276 | [MOL File]
1332295-35-8.mol | [Molecular Weight]
407.44 |
| Chemical Properties | Back Directory | [density ]
1.318±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
14.90±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Nav1.7-IN-2 is an inhibitor of voltage-gated sodium channels (Nav), in particular Nav 1.7, with IC50 of 80 nM.
IC50 value: 80 nM
Target: Nav 1.7
Nav1.7-IN-2 is useful for the treatment of diseases treatable by inhibition of these channels, in particular, chronic pain disorder. The more detailed information please refer to WO 2011103196 A1. Nav1.7-IN-2 is a Nav1.7 channel inhibitor extracted from patent WO/2011103196 A1, compound example J, has an IC50 of 80 nM. | [IC 50]
Nav1.7: 80 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Bregman Howard, et al. Preparation of aryl carboxamide derivatives as sodium channel inhibitors for treatment of pain. From PCT Int. Appl. (2011), WO 2011103196 A1 20110825. |
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| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
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