| Identification | Back Directory | [Name]
1-[[2-(7-Fluoro-3-methyl-2-quinoxalinyl)-5-[(3R)-3-fluoro- 1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]-2-methyl-2-propanol Monohydrate | [CAS]
1332727-40-8 | [Synonyms]
MT-3014
MT3014,MT 3014
1-[[2-(7-Fluoro-3-methyl-2-quinoxalinyl)-5-[(3R)-3-fluoro- 1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]-2-methyl-2-propanol Monohydrate | [Molecular Formula]
C23H25F2N7O | [MDL Number]
MFCD32174295 | [MOL File]
1332727-40-8.mol | [Molecular Weight]
453.49 |
| Hazard Information | Back Directory | [Description]
MT-3014 is a potent, highly selective and brain-penetrated phosphodiesterase 10A (PDE 10A) inhibitor, with IC50s of 0.062 nM and 0.09 nM for human PDE 10A and bovine PDE 10A, respectively[1].
human PDE 10A|0.062 nM (IC50)|bovine PDE 10A|0.09 nM (IC50)
| [Uses]
MT-3014 is a potent, highly selective and brain-penetrated phosphodiesterase 10A (PDE 10A) inhibitor, with IC50s of 0.062 nM and 0.09 nM for human PDE 10A and bovine PDE 10A, respectively[1]. | [IC 50]
human PDE 10A: 0.062 nM (IC50); bovine PDE 10A: 0.09 nM (IC50) | [References]
[1]. Koizumi Y, et al. Discovery of a pyrazolo[1,5-a]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety. Bioorg Med Chem. 2019 Jun 19. |
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