| Identification | Back Directory | [Name]
FETMPYP | [CAS]
133314-07-5 | [Synonyms]
FETMPYP
FEIIITMPYP(CL)
FETMPYP PENTACHLORIDE
FE(III)TETRAKIS(1-METHYL-4-PYRIDYL)PORPHYRIN PENTACHLORIDE
Fe(III) meso-Tetra (N-Methyl-4-Pyridyl) porphine pentachloride
Iron(III) meso -tetra(N-methyl-4-pyridyl)porphine pentachloride
5,10,15,20-tetra (1-methyl-4-pyridyl) porphyrin ferric chloride
5,10,15,20-TETRAKIS(N-METHYL-4'-PYRIDYL)PORPHINATO IRON (III) CHLORIDE | [Molecular Formula]
C45H62N8 | [MDL Number]
MFCD01866383 | [MOL File]
133314-07-5.mol | [Molecular Weight]
715.027 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
0.1 M Tris -HCl, 1 mM EDTA, pH 9.0: >12 mg/ml; PBS pH 7.2: >10.1 mg/ml | [form ]
A crystalline solid | [color ]
Brown to black | [Water Solubility ]
water: 50mg/mL |
| Hazard Information | Back Directory | [Description]
FeTMPyP is a synthetic porphyrin complexed with iron, which acts as a peroxynitrite decomposition catalyst. The rate constant for decomposition of peroxynitrite by FeTMPyP is 2.2 x 106 M−1s−1 with a turnover number of 360 ± 170 s−1.1 The predominant product (>90%) of this reaction is nitrate, with a minor amount of nitrite also formed (~6%), at pH 7.4.1 | [Uses]
FeTMPyP is an orally active peroxynitrite (ONOO ) scavenger. FeTMPyP reduces nitrative stress and increases autophagy. FeTMPyP reduces PARP over-activation and neuroinflammation in chronic constriction injury (CCI)-induced rats, and ameliorates functional, behavioral and biochemical deficits[1][2]. | [References]
[1] Zhang S, et al. Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging. Oxid Med Cell Longev. 2020 Jan 25;2020:4252047. DOI:10.1155/2020/4252047
[2] Komirishetty P, et al. FeTMPyP a peroxynitrite decomposition catalyst ameliorated functional and behavioral deficits in chronic constriction injury induced neuropathic pain in rats. Free Radic Res. 2021 Oct;55(9-10):1005-1017. DOI:10.1080/10715762.2021.2010731 |
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CHATURYA BIOTECH
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www.chaturyabiotech.com |
| Company Name: |
Alfa Chemistry
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https://www.alfa-chemistry.com |
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