| Identification | Back Directory | [Name]
5H-Imidazo[2,1-b][1,3]oxazine, 6,7-dihydro-2-nitro-6-[4-(trifluoromethoxy)phenoxy]- | [CAS]
1333170-15-2 | [Synonyms]
5H-Imidazo[2,1-b][1,3]oxazine, 6,7-dihydro-2-nitro-6-[4-(trifluoromethoxy)phenoxy]- | [Molecular Formula]
C13H10F3N3O5 | [MOL File]
1333170-15-2.mol | [Molecular Weight]
345.23 |
| Hazard Information | Back Directory | [Uses]
(Rac)-DNDI-8219 is an antituberculosis compound with potent anti-leishmanial activity. (Rac)-DNDI-8219 demonstrated superior efficacy in the Leishmania donovani mouse model. (Rac)-DNDI-8219 showed promising activity in the Leishmania infantum hamster model. (Rac)-DNDI-8219 candidate compound R-6 provided excellent oral efficacy in the same hamster model[1]. | [References]
[1] Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis DOI:10.1021/acs.jmedchem.7b01581 |
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