| Identification | Back Directory | [Name]
1-(PERFLUOROHEXYL)OCTANE | [CAS]
133331-77-8 | [Synonyms]
T6-octane
Perfluorohexyl Octane
1-(PERFLUOROHEXYL)OCTANE
1-(Perfluorohexyl)octane 97%
1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluorotetradecane
Tetradecane,1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluoro-
1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluorotetradecane, 1-(Tridecafluorohex-1-yl)octane | [EINECS(EC#)]
432-570-5 | [Molecular Formula]
C14H17F13 | [MDL Number]
MFCD07784188 | [MOL File]
133331-77-8.mol | [Molecular Weight]
432.26 |
| Chemical Properties | Back Directory | [Melting point ]
4.96 °C | [Boiling point ]
340 °C | [density ]
1.331 g/cm3(Temp: 25 °C) | [vapor pressure ]
3.857Pa at 25℃ | [storage temp. ]
Storage temp. 2-8°C | [solubility ]
Ethanol: Sparingly soluble: 1-10 mg/mL | [form ]
liquid | [color ]
Clear | [Water Solubility ]
0.992ng/L at 25℃ | [InChI]
InChI=1S/C14H17F13/c1-2-3-4-5-6-7-8-9(15,16)10(17,18)11(19,20)12(21,22)13(23,24)14(25,26)27/h2-8H2,1H3 | [InChIKey]
WRYIIOKOQSICTB-UHFFFAOYSA-N | [SMILES]
C(F)(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)CCCCCCCC | [LogP]
10.01 at 25℃ | [Surface tension]
19.65mN/m at 298.15K | [EPA Substance Registry System]
1-(Perfluorohexyl)octane (133331-77-8) |
| Hazard Information | Back Directory | [Uses]
1-(Perfluorohexyl)octane is used in preparation of Fluoroalkane by reduction of Halofluoroalkane in presence of precious metal catalyst and inorganic compound. | [Definition]
ChEBI: Perfluorohexyloctane is a fluoroalkane that is tetradecane in which all of the hydrogen atoms at positions 1, 2, 3, 4, 5, and 6 have been replaced by fluorine atoms. It is an ophthalmic solution used to treat the signs and symptoms of dry eye disease. It has a role as an ophthalmology drug and a nonionic surfactant. It is a fluorohydrocarbon and a fluoroalkane. It derives from a hydride of a tetradecane. | [Flammability and Explosibility]
Nonflammable | [Synthesis]
Add 200g of perfluorohexyl iodomethane, 251.6g of 1-octene (5.0eq), 400ml of acetonitrile, 10g of triphenylsilyl mercaptan (catalytic amount) to 1000ml triple-necked vials, dropwise add 91.2g of triethylamine, dropwise add 10g of 2 ,4 ,5 ,6-tetrakis(9 - C | [References]
[1] PRIYANKA AGARWAL . Semifluorinated alkane based systems for enhanced corneal penetration of poorly soluble drugs[J]. International Journal of Pharmaceutics, 2018, 538 1: Pages 119-129. DOI: 10.1016/j.ijpharm.2018.01.019
[2] PRIYANKA AGARWAL . Preclinical studies evaluating the effect of semifluorinated alkanes on ocular surface and tear fluid dynamics[J]. Ocular Surface, 2019, 17 2: Pages 241-249. DOI: 10.1016/j.jtos.2019.02.010 |
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