1333327-56-2

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1333327-56-2 Structure

Identification	Back Directory
[Name] TRC051384
[CAS] 1333327-56-2
[Synonyms] TRC051384 HCl TRC051384 HydrochL TRC051384 Hydrochloride 1-(2-Morpholinoethyl)-3-(4-(3-(6-morpholinopyridin-2-yl)acryloyl)phenyl)urea hydrochloride
[Molecular Formula] C25H32ClN5O4
[MOL File] 1333327-56-2.mol
[Molecular Weight] 502.01

Chemical Properties	Back Directory
[storage temp. ] under inert gas (nitrogen or Argon) at 2-8°C

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H302-H315-H319-H335
[Precautionary statements ] P261-P305+P351+P338

Hazard Information	Back Directory
[Uses] TRC051384 hydrochloride is a potent inducer of heat shock protein 70 (HSP70). TRC051384 hydrochloride exhibits protective effects against neuronal trauma via inhibition of necroptosis. TRC051384 hydrochloride can be used for the research of ischemic stroke[1][2].
[References] [1] Mohanan A, et, al. Delayed intervention in experimental stroke with TRC051384--a small molecule HSP70 inducer. Neuropharmacology. 2011 May;60(6):991-9. DOI:10.1016/j.neuropharm.2010.12.003 [2] Chen T, et, al. HSP70 attenuates neuronal necroptosis through the HSP90α-RIPK3 pathway following neuronal trauma. Mol Biol Rep. 2023 Sep;50(9):7237-7244. DOI:10.1007/s11033-023-08619-7

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