| Identification | Back Directory | [Name]
ND 322 HCl | [CAS]
1333379-23-9 | [Synonyms]
ND322 HCl
ND-322 HCl
ND 322 HCl
ND322 Hydrochloride
ND-322 Hydrochloride
ND 322 Hydrochloride | [Molecular Formula]
C15H15NO3S2.ClH | [MOL File]
1333379-23-9.mol | [Molecular Weight]
357.88 |
| Hazard Information | Back Directory | [Description]
ND-322 HCl is a selective MT1-MMP/MMP2 inhibitor. MT1-MMP and MMP2 have been implicated as pro-tumorigenic and pro-metastatic factors in a wide variety of cancers including melanoma. ND-322 HCl reduces melanoma tumor growth and delays metastatic dissemination. | [Uses]
ND-322 hydrochloride is a potent and selective water-soluble gelatinase inhibitor. ND-322 hydrochloride reduces melanoma tumor growth and delays metastatic dissemination[1][2]. | [References]
[1] Gooyit M, et, al. Selective water-soluble gelatinase inhibitor prodrugs. J Med Chem. 2011 Oct 13;54(19):6676-90. DOI:10.1021/jm200566e
[2] Marusak C, et, al. The thiirane-based selective MT1-MMP/MMP2 inhibitor ND-322 reduces melanoma tumor growth and delays metastatic dissemination. Pharmacol Res. 2016 Nov;113(Pt A):515-520. DOI:10.1016/j.phrs.2016.09.033 |
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