| Identification | Back Directory | [Name]
Regorafenib iMpurity | [CAS]
1333390-56-9 | [Synonyms]
Regorafenib iMpurity
Regorafenib Impurity 30
Regorafenib Urea Impurity
Regorafenib Monohydrate IMP
Regorafenib Monohydrate Impurity
Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(2-fluoro-4-hydroxyphenyl)-
Regorafenib impurity 3/Regorafenib Urea Impurity/1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea | [Molecular Formula]
C14H9ClF4N2O2 | [MDL Number]
MFCD28347630 | [MOL File]
1333390-56-9.mol | [Molecular Weight]
348.68 |
| Questions And Answer | Back Directory | [Uses]
The impurity 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-4-hydroxyphenyl)urea is an impurity with the structure shown below that is generated during the production of regorafenib. Regorafenib is a novel multi-kinase inhibitor developed by Bayer AG. It targets tumorigenesis, tumor angiogenesis, and the maintenance of tumor microenvironment signaling by inhibiting multiple tumor-promoting protein kinases. |
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