| Identification | Back Directory | [Name]
STEM CELL FACTOR, HUMAN | [CAS]
133352-98-4 | [Synonyms]
RHSCF
HUMAN SF
HUMAN SCF
HUMAN MGF
SCF, HUMAN
REC SCF (HUMAN)
C-KIT LIGAND HUMAN
HUMAN C-KIT LIGAND
HUMAN STEEL FACTOR
RECOMBINANT HUMAN SCF
HUMAN STEM CELL FACTOR
HUMAN SCF/C-KIT LIGAND
STEM CELL FACTOR, HUMAN
REC STEM CELL FACTOR (HUMAN)
MAST CELL GROWTH FACTOR HUMAN
HUMAN MAST CELL GROWTH FACTOR
HUMAN STEM CELL FACTOR/C-KIT LIGAND
STEM CELL FACTOR, HUMAN, RECOMBINANT
c-Kit Ligand, Mast Cell Growth Factor (MGF)
STEM CELL FACTOR, HUMAN, RECOMBINANT, E COLI | [MDL Number]
MFCD00165757 |
| Hazard Information | Back Directory | [Uses]
SCF (stem cell factor) is a hematopoietic cytokine that exists in both soluble and transmembrane forms, which arise due to alternative splicing. Both these forms are functionally active. This gene is localized to human chromosome 12q22-12q24. Endothelial cells and fibroblasts constitutively produce both transmembrane and soluble forms of SCF. It is also produced by keratinocytes in normal skin, and epithelial cells in the gut, and thymus. Recombinant human SCF is an 18.4 kDa polypeptide containing 165 amino acid residues, which corresponds to the sequence of the secreted soluble form of SCF. | [General Description]
The KITLG (KIT ligand) gene is mapped to human chromosome 12q21.32. | [Biochem/physiol Actions]
Stem Cell Factor (SCF), also known as c-Kit ligand (KL), steel factor (SLF) and mast cell growth factor (MGF), is a 30 kDa glycoprotein with broad activities on various tissues, including hematopoietic cells, pigment cells, and primordial germ cells. SCF is secreted by endothelial cells, fibroblasts, and bone marrow stromal cells as a membrane-bound form which may be cleaved to release the soluble form. Both forms are active in promoting colony formation from murine bone marrow cells, but membrane-bound SCF is more effective in promoting hematopoieses in vivo, suggesting a role in cellular interactions between hematopoietic and stromal cells. The soluble is thought to exist in solution as a noncovalently linked dimer. SCF is structurally related to M-CSF (CSF-1) and Flt-3/Flk-2 Ligand (FL) with all three sharing a similar size, existence of transmembrane and soluble forms, four conserved cysteines, and alternative splicing exon locations, but they share little sequence homology. SCF alone is a modest colony stimulating factor. However, in the presence of other cytokines such as EPO, TPO, GM-CSF, G-CSF, M-CSF, IL-3, and IL-7, SCF is a potent costimulant that works synergistically to increase the size of myeloid, erythroid or lymphoid lineage colonies without influencing the lineage differentiation of the progenitors. |
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