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133407-83-7

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133407-83-7 Structure

133407-83-7 Structure
IdentificationBack Directory
[Name]

GAMMA-SECRETASE INHIBITOR
[CAS]

133407-83-7
[Synonyms]

Z-LLNLE-CHO
Z-LEU-LEU-NLE-CHO
Z-LEU-LEU-NLE-ALDEHYDE
γ-Secretase Inhibitor I
CBZ-Leu-Leu-Nle-Aldehyde
GAMMA-SECRETASE INHIBITOR
GAMMA-SECRETASE INHIBITOR I
Cbz-leucinyl-leucinyl-norleucinal
L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formylpentyl]-
benzyl N-[4-methyl-1-[[4-methyl-1-oxo-1-(1-oxohexan-2-ylamino)pentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
[Molecular Formula]

C26H41N3O5
[MDL Number]

MFCD02179375
[MOL File]

133407-83-7.mol
[Molecular Weight]

475.62
Chemical PropertiesBack Directory
[storage temp. ]

−20°C
[solubility ]

DMSO: soluble
[form ]

powder
[color ]

White to off-white
[Sensitive ]

Hygroscopic
Safety DataBack Directory
[WGK Germany ]

3
[Storage Class]

11 - Combustible Solids
Hazard InformationBack Directory
[Uses]

gamma-Secretase Inhibitor I is a γ-secretase inhibitor.
[Biological Activity]

Cell permeable: yes''Primary Target
γ-secretase''Product does not compete with ATP.''Reversible: no
[in vivo]

Z-LLNle-CHO (5 mg/kg; s.c.; single daily for 12 days) inhibits engraftment of B-lymphoblasts in precursor-B ALL xenograft model[2].

Animal Model:Female SCID/NOD mice (6-8-week-old; precursor-B ALL xenograft model)[2].
Dosage:5 mg/kg
Administration:Subcutaneous injection; single daily for 12 days
Result:Delayed or prevented engraftment of B-lymphoblasts in 50% of the animals comprising the experimental group.
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