| Identification | Back Directory | [Name]
4-(3-(6-(2-Methoxyethyl)pyridin-3-yl)-2-MethyliMidazo[1,2-a]pyrazin-8-yl)Morpholine | [CAS]
1334165-90-0 | [Synonyms]
4-(3-(6-(2-Methoxyethyl)pyridin-3-yl)-2-MethyliMidazo[1,2-a]pyrazin-8-yl)Morpholine | [Molecular Formula]
C19H23N5O2 | [MDL Number]
MFCD22384939 | [MOL File]
1334165-90-0.mol | [Molecular Weight]
353.418 |
| Hazard Information | Back Directory | [Description]
JNJ-42314415 is a potent, specific, and centrally active PDE10A inhibitor. | [Uses]
JNJ-42314415 is a centrally active phosphodiesterase 10A (PDE10A) inhibitor, with Ki values of 35 nM and 64 nM for human recombinant PDE10A and rPDE10A, respectively[1]. | [in vivo]
JNJ-42314415 with high dose (24.7 mg/kg) induces hypothermia[1]. | [IC 50]
human PDE 10A: 35 nM (Ki) | [References]
[1] Anton A H P Megens, et al. Pharmacology of JNJ-42314415, a centrally active phosphodiesterase 10A (PDE10A) inhibitor: a comparison of PDE10A inhibitors with D2 receptor blockers as potential antipsychotic drugs. J Pharmacol Exp Ther. 2014 Apr;349(1):138-54. DOI:10.1124/jpet.113.211904 |
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