| Identification | Back Directory | [Name]
MPEG8-NH-Mal | [CAS]
1334169-90-2 | [Synonyms]
m-PEG8-Mal
m-dPEG8-MAL
1334169-90-2
MPEG8-NH-Mal
m-dPEG(R)8-MAL
mPEG8-Maleimide
m-PEG8-amido-Mal
Mal-amido-PEG8-Ome
1H-Pyrrole-1-propanamide, 2,5-dihydro-N-3,6,9,12,15,18,21,24-octaoxapentacos-1-yl-2,5-dioxo- | [Molecular Formula]
C24H42N2O11 | [MDL Number]
MFCD13185021 | [MOL File]
1334169-90-2.mol | [Molecular Weight]
534.6 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [form ]
solid or viscous liquid | [InChI]
1S/C24H42N2O11/c1-30-8-9-32-12-13-34-16-17-36-20-21-37-19-18-35-15-14-33-11-10-31-7-5-25-22(27)4-6-26-23(28)2-3-24(26)29/h2-3H,4-21H2,1H3,(H,25,27) | [InChIKey]
DYKKRMSENAYADQ-UHFFFAOYSA-N | [SMILES]
COCCOCCOCCOCCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O |
| Hazard Information | Back Directory | [Description]
m-PEG8-Mal is a PEG linker containing a maleimide group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
m-PEG8-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [reaction suitability]
reactivity: thiol reactive
reagent type: chemical modification reagent
reagent type: cross-linking reagent
reactivity: sulfhydryl reactive | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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