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1334172-64-3

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1334172-64-3 Structure

1334172-64-3 Structure
IdentificationBack Directory
[Name]

Fmoc-Lys (biotin-PEG4)-OH
[CAS]

1334172-64-3
[Synonyms]

Fmoc-Lys (biotin-PEG4)-OH
[Molecular Formula]

C42H59N5O11S
[MDL Number]

MFCD21363320
[MOL File]

1334172-64-3.mol
[Molecular Weight]

842.01
Chemical PropertiesBack Directory
[Boiling point ]

1105.7±65.0 °C(Predicted)
[density ]

1.236±0.06 g/cm3(Predicted)
[pka]

3.87±0.21(Predicted)
Hazard InformationBack Directory
[Description]

Fmoc-Lys (biotin-PEG4)-OH is a Lysine embedded biotin PEG linkers containing a carboxylic group and Fmoc-protected amine. Reaction of carboxylic with primary amino (-NH2) forms stable, irreversible amide bonds. The Fmoc group can be deprotected under basic condition to release the free amine which can be used for further conjugations.
[Uses]

Fmoc-Lys (biotin-PEG4)-OH is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs
[References]

[1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. DOI:10.1038/nchembio.2329
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