| Identification | Back Directory | [Name]
IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID | [CAS]
133427-08-4 | [Synonyms]
Imidazo[1,2-a]pyridine-8-...
Imidazo[1,2-a]pyridine-8-carboxylicaci
8-imidazo[1,2-a]pyridinecarboxylic acid
IMidazo[1,2-a]pyridin-8-carboxylic acid
IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID
H-imidazo[1,2-a]pyridine-8-carboxylic acid
H-iMidazo[1,2-a]pyridine-8-carbo×ylic acid
IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID ISO 9001：2015 REACH | [Molecular Formula]
C8H6N2O2 | [MDL Number]
MFCD06739251 | [MOL File]
133427-08-4.mol | [Molecular Weight]
162.15 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of imidazo[1,2-a]pyridine-8-carboxylic acid from 2-aminonicotinic acid and 2-bromo-1,1-dimethoxyethane: To a suspension of 2-aminonicotinic acid (0.69 g, 5.00 mmol) in acetonitrile (20 mL) was added 2-bromo-1,1-dimethoxyethane (0.59 mL, 5.00 mmol). The resulting mixture was heated to 150 °C in a microwave reactor and kept for 2 hours. After completion of the reaction, the precipitate was collected by filtration and washed sequentially with acetonitrile and hexane to afford imidazo[1,2-a]pyridine-8-carboxylic acid (0.924 g) as a gray solid. | [References]
[1] Patent: WO2009/23253, 2009, A2. Location in patent: Page/Page column 52
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 5, p. 1870 - 1873 |
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