| Identification | Back Directory | [Name]
GSK682753A | [CAS]
1334294-76-6 | [Synonyms]
GSK682753A
EBI2 inhibitor GS682753A
1-Oxa-3,8-diazaspiro[4.5]decan-2-one, 8-[(2E)-3-(4-chlorophenyl)-1-oxo-2-propen-1-yl]-3-[(3,4-dichlorophenyl)methyl]- | [Molecular Formula]
C23H21Cl3N2O3 | [MDL Number]
MFCD30738004 | [MOL File]
1334294-76-6.mol | [Molecular Weight]
479.78 |
| Chemical Properties | Back Directory | [Boiling point ]
731.8±60.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : ≥ 27 mg/mL (56.28 mM) | [form ]
Solid | [pka]
-0.50±0.20(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM. | [References]
[1] Benned-Jensen T, et al. Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist. J Biol Chem. 2011 Aug 19;286(33):29292-302. DOI:10.1074/jbc.M110.196345 |
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| Company Name: |
ChemeGen
|
| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|