| Identification | Back Directory | [Name]
(R)-N-Boc-3-hydroxyadaMantylglycine | [CAS]
1334321-39-9 | [Synonyms]
Boc-3-hydroxy-1-adamantyl-glycine
(R)-N-Boc-3-hydroxyadaMantylglycine
Boc-3-hydroxy-1-adamantyl-L-glycine
(R)-N-Boc-2-(3-hydroxyadamant-1-yl)glycine
Tricyclo[3.3.1.13,7]decane-1-acetic acid, α-[[(1,1-diMethylethoxy)carbonyl]aMino]-3-hydroxy-, (αR)-
(alphaR)-alpha-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-hydroxytricyclo[3.3.1.1(3,7)]decane-1-acetic acid | [Molecular Formula]
C17H27NO5 | [MDL Number]
MFCD16621100 | [MOL File]
1334321-39-9.mol | [Molecular Weight]
325.4 |
| Chemical Properties | Back Directory | [Melting point ]
>280°C (dec.) | [Boiling point ]
497.3±20.0 °C(Predicted) | [density ]
1.296±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
3.93±0.10(Predicted) | [color ]
White to Off-White |
| Questions And Answer | Back Directory | [Uses]
Boc-3-hydroxy-1-adamantyl-glycine is an impurity of Saxagliptin (S143500), which is a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration and has a pharmacokinetic profile compatible with once daily dosing. |
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