| Identification | Back Directory | [Name]
TAI-1 | [CAS]
1334921-03-7 | [Synonyms]
TAI 1;TAI1
TAI-1 USP/EP/BP
TAI 1,TAI1,inhibit,Inhibitor,Apoptosis,TAI-1
N-(4-(4-(4-methoxyphenoxy)-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide
4-Pyridinecarboxamide, N-[4-[4-(4-methoxyphenoxy)-2,6-dimethylphenyl]-2-thiazolyl]- | [Molecular Formula]
C24H21N3O3S | [MDL Number]
MFCD28348371 | [MOL File]
1334921-03-7.mol | [Molecular Weight]
431.51 |
| Chemical Properties | Back Directory | [density ]
1.281±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
≥43.2 mg/mL in DMSO; insoluble in H2O; ≥3.17 mg/mL in EtOH | [form ]
solid | [pka]
5.38±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TAI-1, an orally active anticancer agent, is a highly potent first-in-class Hec1 inhibitor, with a GI50 of 13.48 nM in K562 cells[1]. | [in vivo]
TAI-1 (20 mg/kg intravenously IV/ or 150 mg/kg per oral PO/BID) inhibits tumor growth in multiple cancer xenograft models[1].
| Animal Model: | C.B-17 SCID mice (6-7 weeks, 21-24 g)[1].
| | Dosage: | 20 mg/kg intravenously IV/ or 150 mg/kg per oral PO/BID. | | Administration: | QDx28 cycles. | | Result: | Led to significant tumor growth retardation in Huh-7 and modest tumor inhibition was noted tor the Colo205 and MDA-MB-231 models.
Did not lead to any loss in body weight.
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| [IC 50]
NEK2 | [References]
[1] Lynn Y L Huang, et al. Characterization of the Biological Activity of a Potent Small Molecule Hec1 Inhibitor TAI-1. J Exp Clin Cancer Res. 2014 Jan 9;33(1):6. DOI:10.1186/1756-9966-33-6 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|