| Identification | Back Directory | [Name]
3,6-Diazabicyclo[3.2.0]heptane, 3-(3-quinolinyl)-, (1S,5S)- | [CAS]
1335145-56-6 | [Synonyms]
A424274
A-424274
A 424274
3,6-Diazabicyclo[3.2.0]heptane, 3-(3-quinolinyl)-, (1S,5S)- | [Molecular Formula]
C14H15N3 | [MOL File]
1335145-56-6.mol | [Molecular Weight]
225.29 |
| Hazard Information | Back Directory | [Description]
A-424274 is an α4β2 neuronal nicotinic receptor positive allosteric modulator. | [Uses]
A-424274 is a positive allosteric modulator of the α4β2 neuronal nicotinic acetylcholine receptor with activity to enhance the efficacy of analgesics. A-424274 selectively enhances the potency of a range of nicotinic acetylcholine receptor agonists at the α4β2 receptor and, in preclinical models, co-administration with an α4β2 PAM significantly enhances the analgesic efficacy of ABT-594 at clinically well-tolerated doses in humans. | [References]
[1] α4β2 neuronal nicotinic receptor positive allosteric modulation: an approach for improving the therapeutic index of α4β2 nAChR agonists in pain DOI:10.1016/j.bcp.2011.06.044 |
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