| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Methanol: 5mg/mL,Methanol:PBS (pH 7.2) (1:1): 0.5mg/mL | [form ]
Solid | [color ]
Off-white to light brown |
| Hazard Information | Back Directory | [Uses]
CN128 hydrochloride (CN328) is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia[1]. | [in vivo]
CN128 hydrochloride (450 μmol/kg; p.o.) exhibits a good iron scavenging efficacy in rat[1].
The iron removal efficacies of CN128 displays a dose-dependent behavior[1].
CN128 hydrochloride lacks genetic toxicity[1].
CN128 hydrochloride (75 μmol/kg; i.g.) possesses good oral bioavailability (82.6%), high maximal plasma concentration, and low clearance rats after an oral dose of 75 μmol/kg[1].
CN128 hydrochloride is well-tolerated, with no mortality being observed at the higher dose levels in rats[1].
| Animal Model: | Male SD rats (300 g)[1] | | Dosage: | 450 μmol/kg | | Administration: | Oral gavage, 1 hour after 59Fe-ferritin injection | | Result: | Exhibited good iron scavenging activity. |
| Animal Model: | Sprague-Dawley rats (200~250 g)[1] | | Dosage: | 75 μmol/kg (Pharmacokinetic Analysis) | | Administration: | Oral administration | | Result: | AUC values= 16.38 mg/L?h, Cmax=8.671 mg/L. |
| [storage]
Store at -20°C | [References]
[1] Wenteng Chen, et al. CN128: A New Orally Active Hydroxypyridinone Iron Chelator. J Med Chem. 2020 Apr 23;63(8):4215-4226. DOI:10.1021/acs.jmedchem.0c00137 |
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