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Ara-F-NAD+ is an arabino analogue of NAD+. Ara-F-NAD+ is a potent, reversible and slow-binding CD38 NADase inhibitor[1][2]. | [References]
[1] Berthelier V, et al. Human CD38 is an authentic NAD(P)+ glycohydrolase. Biochem J. 1998;330 ( Pt 3)(Pt 3):1383-1390. doi:10.1042/bj3301383 DOI:10.1042/bj3301383
[2] Wang S, et al. Design, synthesis and SAR studies of NAD analogues as potent inhibitors towards CD38 NADase. Molecules. 2014;19(10):15754-15767. Published 2014 Sep 29. DOI:10.3390/molecules191015754 |
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