| Identification | Back Directory | [Name]
ANANTIN (LINEAR SEQUENCE) | [CAS]
133658-45-4 | [Synonyms]
ANANTIN
ANANTIN (LINEAR SEQUENCE)
anantin from streptomyces coerulescens
GLY-PHE-ILE-GLY-TRP-GLY-ASN-ASP-ILE-PHE-GLY-HIS-TYR-SER-GLY-ASP-PHE
H-GLY-PHE-ILE-GLY-TRP-GLY-ASN-ASP-ILE-PHE-GLY-HIS-TYR-SER-GLY-ASP-PHE-OH
CYCLO[GLY-PHE-ILE-GLY-TRP-GLY-ASN-BETA-ASP]-ILE-PHE-GLY-HIS-TYR-SER-GLY-ASP-PHE
GLY-PHE-ILE-GLY-TRP-GLY-ASN-ASP-ILE-PHE-GLY-HIS-TYR-SER-GLY-ASP-PHE: GFIGWGNDIFGHYSGDF
Cyclo[L-Phe-L-Ile-Gly-L-Trp-Gly-L-Asn-βαAsp-(L-Ile-L-Phe-Gly-L-His-L-Tyr-L-Ser-Gly-L-Asp-L-Phe-OH)-Gly-]
GLY-PHE-ILE-GLY-TRP-GLY-ASN-ASP-ILE-PHE-GLY-HIS-TYR-SER-GLY-ASP-PHE (PEPTIDE BETA BOND BETWEEN GLY1-ASP8 )
Cyclo[L-Phe-L-Ile-Gly-L-Trp-Gly-L-Asn-L-βαAsp-(L-Ile-L-Phe-Gly-L-His-L-Tyr-L-Ser-Gly-L-Asp-L-Phe-OH)-Gly-]
L-Phenylalanine, glycyl-L-phenylalanyl-L-isoleucylglycyl-L-tryptophylglycyl-L-asparaginyl-L-α-aspartyl-L-isoleucyl-L-phenylalanylglycyl-L-histidyl-L-tyrosyl-L-serylglycyl-L-α-aspartyl-, (8→1)-lactam | [Molecular Formula]
C90H111N21O24 | [MDL Number]
MFCD00214206 | [MOL File]
133658-45-4.mol | [Molecular Weight]
1870.97 |
| Hazard Information | Back Directory | [Uses]
Anantin binds competitively to the receptor of atrial natriuretic factor (ANF) from bovine adrenal cortex (Kd = 0.6 μM) and acts as natriuretic peptide receptor A antagonist[1][2]. | [References]
[1] Wyss DF,et al. Anantin--a peptide antagonist of the atrial natriuretic factor (ANF). II. Determination of the primary sequence by NMR on the basis of proton assignments. J Antibiot (Tokyo). 1991 Feb;44(2):172-80.https://pubmed.ncbi.nlm.nih.gov/1826288/1. Wyss DF,et al. Anantin--a peptide antagonist of the atrial natriuretic factor (ANF). II. Determination of the primary sequence by NMR on the basis of proton assignments. J Antibiot (Tokyo). 1991 Feb;44(2):172-80. DOI:10.7164/antibiotics.44.172
[2] Nachshon S, et al. Effects of ANP receptor antagonists on ANP secretion from adult rat cultured atrial myocytes. Am J Physiol. 1995 Mar;268(3 Pt 1):E428-32. DOI:10.1152/ajpendo.1995.268.3.E428 |
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