| Identification | Back Directory | [Name]
RL5a >=98% (HPLC) | [CAS]
133671-66-6 | [Synonyms]
RL5a >=98% (HPLC)
1,2-Ethanediamine, N2-[2-(2-furanyl)-4-quinolinyl]-N1,N1-dimethyl- | [Molecular Formula]
C17H19N3O | [MDL Number]
MFCD00929354 | [MOL File]
133671-66-6.mol | [Molecular Weight]
281.35 |
| Chemical Properties | Back Directory | [Melting point ]
93-95 °C | [Boiling point ]
452.9±45.0 °C(Predicted) | [density ]
1.167±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
9.01±0.28(Predicted) | [color ]
white to very dark brown | [InChI]
1S/C17H19N3O/c1-20(2)10-9-18-15-12-16(17-8-5-11-21-17)19-14-7-4-3-6-13(14)15/h3-8,11-12H,9-10H2,1-2H3,(H,18,19) | [InChIKey]
CRGKLHXVNVZAPA-UHFFFAOYSA-N | [SMILES]
N(CCNc1c2c(nc(c1)c3[o]ccc3)cccc2)(C)C |
| Hazard Information | Back Directory | [Uses]
RL5a (compund C23) is a SETD8 inhibitor[1]. | [Biological Activity]
RL5a is a potent inhibitor of the replication licensing system in human cells. RL5a blocks the binding of the origin recognition complex (ORC) to origin DNAwhich is required interaction for licensing. RL5a appears to act as noncompetitive inhibitor of ORC with respect to ATP. | [References]
[1] https://sci-hub.se/10.1016/j.chembiol.2017.06.019 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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