| Identification | Back Directory | [Name]
N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate | [CAS]
1336913-03-1 | [Synonyms]
PSEM 89S
PSEM 89S TFA
N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate | [Molecular Formula]
C18H23F3N2O5 | [MDL Number]
MFCD31689251 | [MOL File]
1336913-03-1.mol | [Molecular Weight]
404.39 |
| Hazard Information | Back Directory | [Uses]
PSEM 89S TFA is a selective and brain penetrant agonists for the resulting ion channels. PSEM 89S TFA is orthogonally selective for Q79G and L141F, respectively[1]. | [in vivo]
PSEM 89S strongly reduces photostimulation-evoked feeding in mice expressing PSAML141F,Y115F- glycine receptor (GlyR) (30 mg/kg) but not in mice expressing only channelrhodopsin-2 (ChR2) (50 mg/kg)[1].
PSEM 89S (30 mg/kg) shows good brain penetrance in mice after minimally invasive intraperitoneal administration[1]. | Animal Model: | Male Agrp-cre mice (3-6 weeks)[1] | | Dosage: | 30 mg/kg | | Administration: | I.p. administration | | Result: | Almost completely suppressed fos (a marker of neuron activation) in ChR2-expressing neurons. |
| Animal Model: | C57BL/6 mice[1] | | Dosage: | 30 mg/kg (Pharmacokinetic Analysis) | | Administration: | I.p. administration | | Result: | Rised rapidly in serum and brain, and was mostly cleared from both compartments in 1 h. |
| [storage]
Store at -20°C | [References]
[1] Christopher JM, et, al. Chemical and genetic engineering of selective ion channel-ligand interactions. Science. 2011 Sep 2; 333(6047): 1292-6. DOI:10.1126/science.1206606 |
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