| Identification | Back Directory | [Name]
R 80123 | [CAS]
133718-30-6 | [Synonyms]
R 80123
R 80123;R80123
Acetamide, N-cyclohexyl-N-methyl-2-[[(Z)-[phenyl(1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazolin-7-yl)methylene]amino]oxy]- | [Molecular Formula]
C26H29N5O3 | [MDL Number]
MFCD30489748 | [MOL File]
133718-30-6.mol | [Molecular Weight]
459.54 |
| Chemical Properties | Back Directory | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
12.32±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
R 80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor. The fuction is similar to R 80122 (HY-100615, Revizinone).
In vivo: The administration of Revizinone improved the haemodynamic profile with an increase in cardiac output, a decrease in systemic vascular resistance and a stable heart rate and mean arterial blood pressure. [1] With regard to reconstitution of contractility and cardiac function Revizinone (E-isomer) is 10 fold more potent than R 79595 and nearly 100 fold more potent than R 80123 (Z-isomer). [2] Revizinone significantly increases global LV function and systolic wall thickening in ischemic areas at doses greater than or equal to 0.16 mg/kg i.v. [3] | [References]
[1] Vandeplassche GM et al. Comparative effects of R 80122, enoximone, and milrinone on left ventricular phosphodiesterase isoenzymes in vitro and on contractility of normal and stunned myocardium in vivo in dogs. J Cardiovasc Pharmacol. 1992 May;19(5):714-22.
https://www.ncbi.nlm.nih.gov/pubmed/ 1381769 DOI:10.1111/j.1365-2044.1994.tb04409.x
[2] Schneider J et al. Cardiac effects of R 79595 and its isomers (R 80122 and R 80123) in an acute heart failure model. A new class of cardiotonic agents with highly selective phosphodiesterase III inhibitory properties.
Naunyn Schmiedebergs Arch Pharmacol. 1992 Nov;346(5):563-72. DOI:10.1007/BF00169014
[3] Vandeplassche GM et al. Comparative effects of R 80122, enoximone, and milrinone on left ventricular phosphodiesterase isoenzymes in vitro and on contractility of normal and stunned myocardium in vivo in dogs. J Cardiovasc Pharmacol. 1992 May;19(5):714-22. PMID:1381769 |
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