| Identification | Back Directory | [Name]
PD 132301-2 | [CAS]
133825-81-7 | [Synonyms]
PD 132301-2
ATR-101 HCl
Nevanimibe)
ATR-101
(PD-132301
ATR101 hydrochloride
PD-132301 hydrochloride
Nevanimibe hydrochloride | [Molecular Formula]
C27H40ClN3O | [MDL Number]
MFCD00899568 | [MOL File]
133825-81-7.mol | [Molecular Weight]
458.09 |
| Chemical Properties | Back Directory | [storage temp. ]
4°C, away from moisture | [solubility ]
DMSO : 41.67 mg/mL (90.97 mM; Need ultrasonic)| (insoluble) | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
Water : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) | [InChI]
1S/C27H39N3O.ClH/c1-19(2)23-10-9-11-24(20(3)4)25(23)29-26(31)28-18-27(16-7-8-17-27)21-12-14-22(15-13-21)30(5)6;/h9-15,19-20H,7-8,16-18H2,1-6H3,(H2,28,29,31);1H | [InChIKey]
SDOOGTHIDFZUNM-UHFFFAOYSA-N | [SMILES]
[Cl-].N(C)(C)c1ccc(cc1)C3(CCCC3)CNC(=O)Nc2c(cccc2C(C)C)C(C)C.[H+] |
| Hazard Information | Back Directory | [Uses]
Nevanimibe Hydrochloride can be used for combinatory treatment strategies of cancer based on RNA polymerase I inhibition. | [Biological Activity]
ATR-101 (PD 132301-02; Nevanimibe HCl) is an orally activepotent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT1SOAT1) inhibtior (IC50 = 52 nM; intestinal microsome from cholesterol-fed rabbits) th at reduces plasma cholesterol in both acute (by 77%; 50 mg/kg po.) and chronic (by 80%; 10 mg/kg po.) cholesterol-fed r at models. In additionATR-101 is reported to exhibit therapeutic efficacy against adrenocortical carcinoma (ACC)congenital adrenal hyperplasia (CAH)and Cushingμs syndrome (CS). | [IC 50]
ACAT1: 9 nM (EC50); ACAT2: 368 nM (EC50) |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
G-CLONE
|
| Tel: |
400-910-1997 15330005590 |
| Website: |
http://www.g-clone.com/ |
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