ChemicalBook--->CAS DataBase List--->1343476-44-7

1343476-44-7

1343476-44-7 Structure

1343476-44-7 Structure
IdentificationBack Directory
[Name]

Val-Ala-PAB
[CAS]

1343476-44-7
[Synonyms]

CS-2747
Val-Ala-PAB
Val-Ala-PAB-OH
L-Alaninamide, L-valyl-N-[4-(hydroxymethyl)phenyl]-
(2S)-2-amino-N-[(2S)-1-[4-(hydroxymethyl)anilino]-1-oxopropan-2-yl]-3-methylbutanamide
(S)-2-Amino-N-((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)-3-methylbutanamide
[Molecular Formula]

C15H23N3O3
[MDL Number]

MFCD32641649
[MOL File]

1343476-44-7.mol
[Molecular Weight]

293.36
Chemical PropertiesBack Directory
[Melting point ]

65-68°C
[Boiling point ]

584.9±50.0 °C(Predicted)
[density ]

1.191±0.06 g/cm3(Predicted)
[storage temp. ]

-20°C, Inert atmosphere
[solubility ]

DMSO (Slightly), Methanol (Slightly)
[form ]

Solid
[pka]

13.51±0.70(Predicted)
[color ]

White to Off-White
Hazard InformationBack Directory
[Description]

Val-Ala-PAB-OH is a cleavable ADC linker with a terminal hydroxyl group. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
[Uses]

Val-Ala-PAB is a building block in the synthesis of Tesirine (a.k.a. SG3249), a clinical antibody-drug conjugate pyrrolobenzodiazepine dimer payload. Reagent in the preparation of pyrrolobenzodiazepine dimers and their antibody conjugates containing peptide linkers useful for treating proliferative including cancer.
Spectrum DetailBack Directory
[Spectrum Detail]

Val-Ala-PAB(1343476-44-7)1HNMR
1343476-44-7 suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Website: www.atkchemical.com
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website: www.targetmol.com/
Company Name: Henan Aochuang Chemical Co.,Ltd.
Tel: +86-0371-63689365 +8618638391208 , +8618638391208
Website: http://www.aochuangchem.com/
Company Name: TargetMol Chemicals Inc.
Tel:
Website: www.targetmol.com/
Company Name: Shanxi Tihondan Pharmaceutical Technology Co., Ltd
Tel: +8618235132063 , +8618235132063
Website: www.tihondan.com/web/#/
Company Name: Jilin Chinese Academy of Sciences-yanshen Technology
Tel: +undefined18143011203 , +undefined18143011203
Website: www.chemextension.com/
Company Name: Xian confluore Biological Technology Co., Ltd.
Tel: +86-15680926068 +86-15680926068 , +86-15680926068
Website: http://www.confluore.com/
Company Name: Qingdao RENAS Polymer Material Co., Ltd.
Tel: +86-0532-86867058 +86-18562606086 , +86-18562606086
Website: www.qdrenas.com
Company Name: Wuhan Jingkang en Biomedical Technology Co., Ltd
Tel: +8613720134139 , +8613720134139
Website: http://www.jknbiochem.com/
Company Name: Shenzhen Yuzhong Pharmaceutical Technology Co., Ltd.  Gold
Tel: 13414494621
Website: https://www.chemicalbook.com/ShowSupplierProductsList31078/0.htm
Company Name: Nanjing Chemlin Chemical Co., Ltd  
Tel: 025-83697070
Website: www.echemlin.cn
Company Name: Tianjin Chempharmatech Co.,Ltd.  
Tel: 022-66211079 13212288319
Website: www.chempharmatech.com
Company Name: Hygeia (Chengdu) pharmaceutical technique Co., Ltd  
Tel: 028-84502008 13568869383
Website: http://www.hygeiapharm.com
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
Tel: 021-52996696,15000506266 15000506266
Website: http://www.bioll.com
Company Name: Shanghai Send Pharmaceutical Technology Co., Ltd.  
Tel: 021-58088081 Q2816483246
Website: www.shsendpharma.com
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: 021-QQ:65489617 15618227136
Website: www.atkchemical.com/
Company Name: Shanghai SuperLan Chemcial Technique Centre  
Tel: 021-2022843681 15618226720
Website: https://www.chemicalbook.com/ShowSupplierProductsList19886/0.htm
Company Name: Heze Development Zone chuangli Chemical Co., Ltd.  
Tel: 0530-+86-530-529 6766,+86-15666160102 15666160102
Website: www.chemicalbook.com/supplier/10660012/
Tags:1343476-44-7 Related Product Information

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.