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Ro 09-1428 is a parenteral cephalosporin with high antipseudomonal activity. | [Uses]
Ro 09-1428 is a broad-spectrum parenteral cephalosporin. Ro 09-1428 has potent antibacterial activities against Pseudomonas aeruginosa and Acinetobacter caloaceticus, with MIC90s of 0.39 and 6.25 μg/mL, respectively, better than Ceftazidime (HY-B0593). Additionally, Ro 09-1428 shows high activity against Escherichia coli, Kkbsielia pneumoniae, Proteus mirabilis, P. aeruginosa, staphylococci, and more. Ro 09-1428 preferentially attacks PBP 3 for target in E. coli and P. aeruginosa, which is promising for research of septicemias and serious P. aeruginosa infections[1][2]. | [References]
[1] Arisawa M, et al. In vitro and in vivo evaluation of Ro 09-1428, a new parenteral cephalosporin with high antipseudomonal activity. Antimicrob Agents Chemother. 1991 Apr;35(4):653-9. DOI:10.1128/AAC.35.4.653
[2] Jones R N, et al. In vitro evaluation of Ro 09-1227, a novel catechol-substituted cephalosporin[J]. Antimicrobial agents and chemotherapy, 1992, 36(1): 233-238. DOI:10.1128/AAC.36.1.233 |
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